Lab to Company · LAB TO COMPANY 004 · A large company spins out a team
Isomorphic Labs: spun out of DeepMind, while Google keeps the AlphaFold 3 licence
The question · When a parent turns a landmark piece of research into a company, what does it hand over, and what does it keep?
At a glance · Alphabet registered as holding 75%-plus since the day the company was incorporated; first money £88.66M; AlphaFold 3's weights and output terms say it "belongs to us", and "us" is Google.
One of the Lab to Company series. Each piece reads the public record through five roles: who supplies the research (the results, methods or team it came from), who holds the IP (patents, licences, what a parent kept), who gives the lab and equipment, who puts in the first money and on what terms, and who joins the company. It records only what the public record states and says who said each thing; a missing step is marked not yet public, and a company's own figure is written as the company's.
Isomorphic Labs designs drugs with AI. Demis Hassabis announced it on 1 November 2021 to build on DeepMind's AlphaFold 2, as CEO of both.[1] Companies House shows it had been incorporated on 24 February 2021, eight months before the launch.[3] It is the series' case of the deepest parent: the money, the founders and control came from Alphabet, AlphaFold 3 was built by both, and the model's licence terms are Google's.[3][6][7]
Who supplies the research · DeepMind, then both together. Colin Murdoch told CNBC that after AlphaFold 2 he and Hassabis gathered DeepMind staff to explore uses and pitched a business plan to Alphabet; CNBC adds that not all of those staff stayed after the spin-out, and the team had to be hired from scratch.[2] AlphaFold 3 was built by Google DeepMind and Isomorphic: 11 of the Nature paper's 48 authors are at Isomorphic, and the research was led by Hassabis, Max Jaderberg and John Jumper.[6] The accounts also show Isomorphic buying R&D services from other group companies (about £10.6M in 2025), without naming which.[5]
Who holds the IP · What is public sits with Google. AlphaFold 3's code is copyright DeepMind Technologies; the weights and output are contracts with Google, whose output terms say AlphaFold 3 "belongs to us" and allow non-commercial use only; commercial use is bought through Google Cloud.[7][8][9] The paper says "author-affiliated entities" filed US provisional patent applications, without saying whether Google or Isomorphic.[6] Whether Isomorphic co-owns or exclusively licenses AlphaFold, and whether it pays, is not yet public; in 2021 it bought £3.55M of intangible assets, and the accounts do not say what or from whom.[4] It calls its drug-design engine, IsoDDE, its own proprietary platform.[5]
Who gives the lab and equipment · Mostly computing, with wet work done by partners. The London headquarters is in King's Cross, where in early 2022 "just over a dozen people" worked from a temporary office; a Lausanne office opened in 2023, where the company says "much of our work happens inside computers"; the Swiss subsidiary is registered care of Google Switzerland.[2][13][5] No owned wet lab appears: the UK company's balance sheet holds no tangible fixed assets, and in the J&J deal Isomorphic designs and predicts while J&J runs the assays.[5][12] Who supplies compute, and on what terms, is not public.[5]
Who puts in the first money, and on what terms · Alphabet. The filings show the UK company issuing shares to its US parent, Isomorphic Holdings LLC, for £88.66M in cash on 19 November 2021; CNBC says "the check came in November 2021" and that the company has never said how much Google first invested.[3][2] The first outside round came in March 2025: $600M led by Thrive Capital, with GV and follow-on from Alphabet; the May 2026 Series B raised $2.1B, again led by Thrive, and neither disclosed a valuation.[10][11] After the outside money Companies House still lists Alphabet as the sole person with significant control, at 75%-plus with the right to appoint directors.[3] The UK company lost £159M in 2025 against £55M of income from its pharma deals, with no milestone yet achieved.[5]
Who joins the company · Half from DeepMind, half from drugmaking and tech. From DeepMind: Hassabis (CEO), business lead Colin Murdoch (later president, an adviser from 2026), Max Jaderberg (chief AI officer, president from 2026) and people lead Beverley Mallon.[2][14][15] From outside: chief scientific officer Miles Congreve (formerly CSO of Sosei Heptares), CTO Sergei Yakneen (formerly CTO of SOPHiA GENETICS, no longer on today's team page) and chief medical officer Ben Wolf, from Relay Therapeutics.[14] Average headcount was 225 in 2025, and the company said it had passed 300 by the end of that year.[5][15]
What each side put in
- Alphabet put in the founders, the AlphaFold research and all the money until 2025, and kept control, as well as AlphaFold 3's outside licensing and commercial sales.[3][7][9]
- Isomorphic put in half of the AlphaFold 3 research and its own drug-design engine, which became its deals with Lilly, Novartis and J&J.[6][5]
- Outside investors put in $2.7B and joined a company Alphabet still controls.[10][11][3]
Not yet public · Any AlphaFold licence from DeepMind or Google to Isomorphic and its fees; who owns the AlphaFold 3 patents; what the 2021 intangibles were; Alphabet's total commitment and its stake after the outside rounds; the valuations, share classes and board at the holding company; who supplies compute; which DeepMind staff moved over in 2021.
Decision point · The next decision belongs to the pharma partners: the 2025 accounts show no milestone yet achieved, and when the first milestone payment is triggered will be their first acceptance of the engine.[5] The Buyer Chains control case on Isomorphic is waiting on the same step.
The chain's timeline
- 2020–2021After AlphaFold 2, Murdoch and Hassabis pitch a business plan to Alphabet (Murdoch's account to CNBC)[2]
- 2021-02-24UK company incorporated, Alphabet as person with significant control[3]
- 2021-11-01Public launch; Hassabis CEO of both[1]
- 2021-11-19£88.66M paid in[3]
- 2022-05Congreve, Yakneen and Jaderberg join the leadership[14]
- 2024-05AlphaFold 3 published, 11 authors at Isomorphic[6]
- 2025-03First outside round, $600M[10]
- 2026-01Jaderberg becomes president; J&J collaboration[15][12]
- 2026-05$2.1B Series B[11]
- NextThe first milestone payment; the first molecule into the clinic. Awaiting public data.
- LaterWhether the split of AlphaFold rights between Google and Isomorphic is ever made public.
Sources
- Isomorphic Labs, "Introducing Isomorphic Labs", 2021-11-01. isomorphiclabs.com ↗ (read in full)
- CNBC, 2025-04-09 (NBC Washington's copy). nbcwashington.com ↗ (read in full)
- Companies House, Isomorphic Labs Limited (13223825): overview, persons with significant control, officers and share allotments. find-and-update.company-information.service.gov.uk ↗ (read)
- Same, accounts for 2021. find-and-update.company-information.service.gov.uk ↗ (all 21 pages read by OCR)
- Same, accounts for 2025, signed 2026-07-07. find-and-update.company-information.service.gov.uk ↗ (all 27 pages read by OCR)
- Abramson et al., AlphaFold 3, Nature 2024 (Europe PMC full text). europepmc.org ↗ (affiliations, contributions, competing interests and code availability read)
- AlphaFold 3 weights terms of use. github.com ↗ (key clauses read)
- AlphaFold 3 output terms of use. github.com ↗ (key clauses read)
- AlphaFold 3 repository README. github.com ↗ (licence and commercial-use sections read)
- Isomorphic Labs, $600M funding release, 2025-03-31. prnewswire.com ↗ (read in full)
- Isomorphic Labs, Series B release, 2026-05-12. isomorphiclabs.com ↗ (read in full)
- Isomorphic Labs, J&J collaboration release, 2026-01. storage.googleapis.com ↗ (the division-of-work passage read)
- Isomorphic Labs, Lausanne office post, 2025-11-13. isomorphiclabs.com ↗ (read in full)
- Isomorphic Labs team page and 2022 leadership announcement. isomorphiclabs.com ↗ (read in full)
- Isomorphic Labs, Jaderberg named president, 2025-11. storage.googleapis.com ↗ (read in full)

