Ali Madani
Researcher · Founder
Now Founder, Profluent
Latest on AI4S.fyiTimeline · Sep 30Profluent and BioMarin agree to design enzyme replacement therapies with Profluent's protein models, on terms neither namesAccount linked from madani.ai · Avatar from their X account, taken 2026-09-28
Affiliations
Current
- Founder · Profluent
Current roles come from these dated records, not from the bio below. Each links the page it was read from.
About
Ali Madani is the chief executive of Profluent. He is a machine learning researcher with a PhD from UC Berkeley, and before Profluent he was the architect of the ProGen project at Salesforce AI Research, which showed that large language models can generate functional protein sequences from scratch.
Read on 2026-09-29; for current roles see Affiliations above. Read at: profluent.bio ↗
Selected work
- Large language models generate functional protein sequences across diverse families ↗
ProGen, a language model that generates protein sequences; some generated enzymes were tested for function in the lab.
Each byline was read on the paper itself. Only people on this record are named, not the full author list, and a shared byline does not say who did which part.
Founded
ProfluentProtein design · 2022 · 3 rounds on record · disclosed $150M · Round (unnamed) $106MBackground: Salesforce Research (led ML research; ProGen) (as the company's own announcements put it)
Backed byAltimeter CapitalBezos ExpeditionsSpark CapitalInsight Partners
On the timeline
- 2026-09-30Profluent and BioMarin agree to design enzyme replacement therapies with Profluent's protein models, on terms neither names
- 2026-04-28Lilly will license recombinases Profluent is to design with AI, enzymes for writing long DNA into the genome: upfront undisclosed, up to $2.25B in milestones
- 2025-07-30Profluent's language-model-designed gene editor OpenCRISPR-1 edits human cells, in Nature
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