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Profluent

United StatesProtein designEmeryville, California, United StatesFounded 2022Private

Website · profluent.bio ↗

Trains large protein language models (ProGen3) on its own protein atlas to design gene editors, antibodies and enzymes, and licenses the designs.

Disclosed total$150M
Rounds on record3
Latest round$106MRound (unnamed) · 2025-11-19
Last stated valuationNone stated
Investors named8
Research on record1highest level 4 · Tested in the physical world

Money and evidence

Moneyeach round in US dollars; ≈ converted at its date2023202420252026$9M$35M$106MEvidencelevel of each research entry12345
Closed roundResearch entry, at its level

Latest round, Round (unnamed), 2025-11-19: the record then held 1 research entry, highest level 4. The first research entry is dated 2025-07-30; the highest level so far is 4 (Tested in the physical world).

Rounds and research, on one timeline

  1. 2025-11-19Round (unnamed)
    Round

    $106M

    For: expand platform and markets beyond gene editors

    Models and platformCommercial roll-out

    Release names no series; total funding $150M.

    Co-lead · Altimeter CapitalCo-lead · Bezos ExpeditionsSpark Capital ✓Insight Partners ✓Air Street Capital ✓

    On the deal: Jamin Ball (Partner, Altimeter Capital)

    By this date the record held 1 research entry, highest level 4

    Announced by the company · finance.yahoo.com ↗

  2. 2025-07-30
    Research

    Level 4 · Tested in the physical world

    Profluent's language-model-designed gene editor OpenCRISPR-1 edits human cells, in Nature

    A generated protein was made and run in human cells, past a score on a screen. Profluent wrote and ran the tests, and the abstract reports no test in animals or patients.

    Timeline entry →doi.org ↗

  3. 2024-03-21Round (unnamed)
    Round

    $35M

    For: scale LLMs and datasets, wet lab, CRISPR gene editing

    Models and platformData generationWet lab

    Release does not name a series (Air Street calls it Series A); total raised $44M.

    Lead · Spark Capital ✓Insight Partners ✓Air Street Capital ✓Jeff Dean (angel)

    On the deal: Fraser Kelton (General Partner, Spark Capital, joins the board); Jeff Dean (Angel investor); Nabeel Hyatt (General Partner, Spark Capital, joins the board)

    Announced by the company · crisprmedicinenews.com ↗

  4. 2023-01-26Seed
    Round

    $9M

    For: build a wet lab in Berkeley and hire

    Wet labHiring

    Lead · Insight Partners ✓Air Street Capital ✓AIX Ventures ✓Phoenix Venture Partners

    On the deal: Dylan Morris (Managing Director, Insight Partners); Nathan Benaich (General Partner, Air Street Capital)

    Announced by the company · profluent.bio ↗

Research entries are the timeline's graded entries that name this company. A level grades one claim, not the company, and a blank can mean the record has not caught up rather than that nothing was published.

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On the investors' own sites

Investors that name this company on their own site, in a portfolio or their own announcement. A ✓ in a round marks the same investor.

Its investors also backed

Other companies on this page whose rounds name the same investor.