ETH Zurich

Research on the record

• 2026-10-14Designed from scratch, 13 of 69 cysteine proteases cut the peptide backbone where told, and designs cut their targets in cellsLevel 4 · Tested in the physical world
• 2026-10-14Zinc proteases designed with RFdiffusion cut chosen peptide bonds, and some cut TDP-43 and amyloid-betaLevel 4 · Tested in the physical world
• 2026-10-09Roche and ETH Zurich let one model choose which borylation reactions to run, and a second, trained on the result, called where the reaction lands on ten new ring compoundsLevel 4 · Tested in the physical world
• 2026-09-25Mila and ETH Zurich rebuild DFT's basis set as a cloud of Gaussians fitted by gradient descent, reaching 2,742 atoms on one four-GPU nodeLevel 2 · Computed
• 2026-09-22AI-written carrier parts for antibiotic assembly-line enzymes work in living cells: 76 designs, 578 variants built and measured, yields up to three times the natural partLevel 4 · Tested in the physical world

Graded by how far the evidence went, not how good the result is. See the methodology.

Read on AI4S.fyi

• 2026-10-15De novo cysteine proteases: 13 of 69 cut, and they cut inside living cellsBrief
• 2026-10-15Designed zinc proteases: 135 designs in one shot, 36% cut at the bond they were told toBrief
• 2026-10-19AI for Science: six lessons from 60 papersCommentaryJorge Bravo-Abad · Discovery at Scale

People

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