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EvolutionaryScale

United StatesProtein designNew York, United StatesFounded 2023Team joined another organisation

Website · evolutionaryscale.ai ↗

Built ESM protein language models, including ESM3, which reasons over protein sequence, structure and function to generate new proteins.

In November 2025 its team joined Biohub, the Chan Zuckerberg research organisation, in a strategic transaction with CZI; co-founder Alex Rives became Biohub's head of science. Terms not disclosed in the counsel's note.

Disclosed total-
Rounds on record1
Latest roundmore than $142 millionSeed · 2024-06-25
Last stated valuationNone stated
Investors named5
Research on record1highest level 4 · Tested in the physical world

Money and evidence

Moneyeach round in US dollars; ≈ converted at its date20252026$142MEvidencelevel of each research entry12345
Closed roundResearch entry, at its level

Latest round, Seed, 2024-06-25: the record then held 1 research entry, highest level 4. The first research entry is dated 2024-06-25; the highest level so far is 4 (Tested in the physical world).

Rounds and research, on one timeline

  1. 2024-06-25
    Research

    Level 4 · Tested in the physical world

    EvolutionaryScale's ESM3 protein model writes a green fluorescent protein only 58% identical to any known one, and in the lab it glows about as brightly as natural GFP

    Engineered GFPs usually carry 5 to 15 mutations, and at most 40 to 50 with machine learning; esmGFP is 96 of 229 residues from its closest known relative, a gap the authors estimate evolution takes over 500 million years to open. So a working function was made far from known sequences and shown in the lab, not only predicted. The test is narrow: one protein family, the authors' own assays, two plates of designs, fluorescence measured in bacteria, no solved structure. A 1.4-billion-parameter model was released openly; Science published the paper in January 2025.

    Timeline entry →doi.org ↗

  2. 2024-06-25Seed
    Round

    more than $142 million

    For: expand the capabilities of its models

    Models and platform

    Co-lead · Nat FriedmanCo-lead · Daniel GrossCo-lead · Lux Capital ✓Amazon ✓NVentures (NVIDIA)

    On the deal: Daniel Gross (Individual investor; co-lead); Nat Friedman (Individual investor; co-lead)

    The investor's own page says · Amazon: Seed (2024-06-25)

    The investor's own page says · Lux Capital: 2023

    By this date the record held 1 research entry, highest level 4

    Announced by the company · press.aboutamazon.com ↗

Research entries are the timeline's graded entries that name this company. A level grades one claim, not the company, and a blank can mean the record has not caught up rather than that nothing was published.

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On the investors' own sites

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